Kaim Bidiwala
King's College London, United KingdomPresentation Title:
Involvement of the midbrain in locomotion of the xenopus laevis tadpole
Abstract
The study explores the role of the midbrain in locomotion control in Xenopus laevis tadpoles, at developmental stage 37/38, focusing on the Trunk Skin Pathway. We aimed to ascertain the level of involvement of the TSP through the creation of various lesions within its midbrain, with the trigeminal cut as the control group. Locomotion can also be initiated via the press head, touch head & light dimming pathways (Jamieson and Roberts, 2000). Statistical tests were conducted & signifance analysed using SPSS software.
Astonishing results obtained through the study can be summarized into the following 3 points:
1. The hindbrain alone is able to generate motor responses without the assistance of the midbrain.
2. The Right side of the nervous system perhaps has a stronger role in locomotion than the left.
3. The posture of the animal prior to being initiated may also have an impact on its first motor movement.
Results suggest that the hindbrain may have a more significant role in movement control than previously believed, even after lesions in the midbrain hindbrain border.
Findings also reveal the impact of midline lesions on movement control, with the right group showing slower responses but requiring less intensity, indicating potential differences in neuronal function between the right and left sides of the midbrain. The right group also displayed a higher propensity for ipsilateral movement, highlighting the potential involvement of the right side in motor direction control.
Additionally, animals exhibiting ipsilateral head bends more likely to show ipsilateral movements.
By unraveling the complex neural pathways involved in movement control, this study may lead to the development of novel therapies for patients with motor disorders & potential treatment approaches. Furthermore, it lays the groundwork for future research in understanding the fundamental mechanisms of locomotion in vertebrates, offering opportunities for advancements in neuroscience.
Biography
Kaim is currently a third-year medical student and a qualified Pharmacist who completed his training in both hospital & primary care setting. He has also undertaken a Diploma in Mental Health, alongside obtaining certificates in Islamic Psychology and Counselling. He has trained as a NICE champion, emphasizing evidence-based medicine and collaborating with peers to implement NICE techniques. Moreover, he has taken on several senior leadership & advisory roles across numerous universities within the United Kingdom, over the past 5 years.
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