David J Dickoff

Metropolitan Neurological Consultants, USA

Title: Restless Limbs Syndrome (RLS): Natural History and Augmentation

Abstract

The natural history of RLS is not well-defined. Dopamine Agonists (DA) have side effects including augmentation which can cause symptoms to worsen, occur earlier, and spread. The precise incidence of augmentation is unknown. 983 patients with RLS completed a survey addressing location and diurnal variation of symptoms at onset (age 38 years) and presentation (age 53). 772 received DAs (M) and 1,02 did not (NM). The groups were compared for progression. M and NM groups were matched at onset for age, gender, leg onset (58.8% vs 57.8%); and nocturnal onset (46.3%vs 52.7Yo).At presentation symptoms involved anns n 56.2% M and 49.5% NM (p:0.68). Symptoms became diurnal in 74%lMand73.4YaNM (p:0.50). 120 of 772 M patients (15.5%) experienced worsening of symptoms or side effects. 36 described changes suggesting augmentation: worsening of pain/symptoms (22), earlier onset (5), or shorter effects of medication (9). These data support that the natural history of RLS includes spread of symptoms over space and time. This progression was not significantly different befween medicated and non-medicated groups.

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2nd International Conference on Neurology and Brain Disorders

David J Dickoff

Title: Restless Limbs Syndrome (RLS): Natural History and Augmentation

Abstract

Biography

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